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Flunixin
Flunixin is a non-steroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in horses, cattle and pigs. It is often formulated as the meglumine salt. In the United States, it is regulated by the ] (FDA), and may only be lawfully distributed by order of a licensed veterinarian. There are many trade names for the product, as stated below.
==Dosage and uses in horses==
Flunixin is administered at a dose of 1.1 mg/kg.〔McIlwraith CW, Frisbie DD, Kawcak CE. Nonsteroidal Anti-Inflammatory Drugs. Proc. AAEP 2001 (47): 182-187.〕 The full analgesic and antipyretic effects usually occur 1-2 hours following treatment, but there is often an effective analgesic effect within approximately 15 minutes. Despite its short plasma half life of 1.6-2.5 hours, effects can persist for up to 30 hours,〔May SA, Lees P. Nonsteroidal anti-inflammatory drugs. In McIlwraith CW, Trotter GW, eds. Joint disease in the horse. Philadelphia: WB Saunders, 1996;223–237.〕 with maximal effects occurring between 2 and 16 hours. This is likely due to accumulation of the drug as an inflammatory foci.
Because it targets the inflamed tissue, flunixin is mainly used for colic pain, muscle pain, and joint disease, as well as to alleviate fevers and pain, and prevent endotoxemia. It is also effective in injuries of the eye.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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